01.10.2025
19.03.2026
Ixekizumab (6)
Taltz®
Lilly Deutschland GmbH
Musculoskeletal system diseases
Enthesitis-associated arthritis, ≥ 6 years
240–290
100%
additional benefit not proven
15.09.2025
05.03.2026
Avacopan (2)
Tavneos®
Fresenius Medical Care Nephrologica Deutschland
Musculoskeletal system diseases
Granulomatosis with polyangiitis or microscopic polyangiitis, in combination with rituximab or cyclophosphamide
2,330–2,850
100%
additional benefit not proven
Orphan (turnover limit)
15.07.2025
22.01.2026
Givinostat (1)
Duvyzat®
ITF Pharma GmbH
Musculoskeletal system diseases
Duchenne muscular dystrophy, ≥ 6 years, in combination with a corticosteroid
270–400
100%
Hint for
non-quantifiable additional benefit
Orphan
15.05.2025
06.11.2025
Upadacitinib (8)
Rinvoq®
AbbVie Deutschland GmbH & Co. KG
Musculoskeletal system diseases
Giant cell arteritis
13,100–15,900
20%
Hint for
minor additional benefit
15.02.2025
07.08.2025
Sarilumab (2)
Kevzara®
Sanofi-Aventis Deutschland GmbH
Musculoskeletal system diseases
Polyarticular juvenile idiopathic arthritis (pJIA), ≥ 2 years
1,370–1,480
100%
additional benefit not proven
15.02.2025
07.08.2025
Sarilumab (3)
Kevzara®
Sanofi-Aventis Deutschland GmbH
Musculoskeletal system diseases
Polymyalgia rheumatica
10,300–14,200
100%
additional benefit not proven
01.12.2024
15.05.2025
Benralizumab (2)
Fasenra®
AstraZeneca GmbH
Musculoskeletal system diseases
Eosinophilic granulomatosis with polyangiitis
90–1,360
100%
additional benefit not proven
15.04.2024
02.10.2024
Abaloparatid (1)
Eladynos®
Theramex Germany GmbH
Musculoskeletal system diseases
Osteoporosis, postmenopausal women
484,000
100%
additional benefit not proven
15.01.2024
04.07.2024
Vamorolon (1)
Agamree®
Santhera Pharmaceuticals GmbH
Musculoskeletal system diseases
Duchenne muscular dystrophy, ≥ 4 years
740–3,670
100%
Hint for
non-quantifiable additional benefit
Orphan
15.11.2023
02.05.2024
Baricitinib (3)
Olumiant®
Lilly Deutschland GmbH
Musculoskeletal system diseases
Polyarticular juvenile idiopathic Arthritis, RF+ or RF− polyarticular and expanded oligoarticular, ≥ 2 years
1,370–1,410
100%
additional benefit not proven
15.11.2023
02.05.2024
Baricitinib (5)
Olumiant®
Lilly Deutschland GmbH
Musculoskeletal system diseases
Enthesitis-associated arthritis, ≥ 2 years
330–390
100%
additional benefit not proven
01.07.2023
21.12.2023
Bimekizumab (3)
Bimzelx®
UCB Pharma GmbH
Musculoskeletal system diseases
Ankylosing spondylitis
16,800
100%
additional benefit not proven
01.07.2023
21.12.2023
Bimekizumab (4)
Bimzelx®
UCB Pharma GmbH
Musculoskeletal system diseases
Axial spondyloarthritis, non-radiographic
19,500
100%
additional benefit not proven
01.03.2023
17.08.2023
Voclosporin (1)
Lupkynis®
Otsuka Pharma GmbH
Musculoskeletal system diseases
Lupusnephritis
1,090–13,050
100%
additional benefit not proven
01.09.2022
16.02.2023
Upadacitinib (6)
Rinvoq®
AbbVie Deutschland GmbH & Co. KG
Musculoskeletal system diseases
Axial spondyloarthritis (AS), non-radiographic
19,500
100%
additional benefit not proven
15.07.2022
05.01.2023
Secukinumab (7)
Cosentyx®
Novartis Pharma GmbH
Musculoskeletal system diseases
Enthesitis-related arthritis (ERA)
240–290
100%
additional benefit not proven
01.04.2022
06.10.2022
Anifrolumab (1)
Saphnelo®
AstraZeneca GmbH
Musculoskeletal system diseases
Systemic lupus erythematosus (SLE)
4,600–18,500
100%
additional benefit not proven
15.02.2022
04.08.2022
Avacopan (1)
Tavneos®
Vifor Pharma Deutschland GmbH
Musculoskeletal system diseases
Granulomatosis with polyangiitis or microscopic polyangiitis, combination with rituximab or cyclophosphamide
0
2,180–2,280
100%
Hint for
minor additional benefit
Orphan
repealed
15.12.2021
16.06.2022
Tofacitinib (7)
Xeljanz®
Pfizer Pharma GmbH
Musculoskeletal system diseases
Ankylosing spondylitis (AS)
16,800
100%
additional benefit not proven
01.12.2021
19.05.2022
Mepolizumab (4)
Nucala®
GlaxoSmithKline GmbH & Co. KG
Musculoskeletal system diseases
Eosinophilic granulomatosis with polyangiitis
80–1,130
100%
additional benefit not proven
15.09.2021
03.03.2022
Tofacitinib (6)
Xeljanz®
Pfizer Pharma GmbH
Musculoskeletal system diseases
Polyarticular juvenile idiopathic arthritis, RF+ or RF polyarthritis and dilated oligoarthritis, and juvenile psoriatic arthritis, ≥ 2 years
1,450
100%
additional benefit not proven
01.09.2021
17.02.2022
Tofacitinib (5)
Xeljanz®
Pfizer Pharma GmbH
Musculoskeletal system diseases
Rheumatoid arthritis (RA), pretreated patients, monotherapy or combination with methotrexate
27,100–93,500
100%
additional benefit not proven
01.02.2021
15.07.2021
Upadacitinib (3)
Rinvoq®
AbbVie Deutschland GmbH & Co. KG
Musculoskeletal system diseases
Ankylosing spondylitis
7,800–16,800
100%
additional benefit not proven
15.10.2020
15.04.2021
Filgotinib (1)
Jyseleca®
Gilead Sciences GmbH
Musculoskeletal system diseases
Rheumatoid arthritis (RA)
89,710–193,750
33%
Hint for
minor additional benefit
01.09.2020
18.02.2021
Secukinumab (6)
Cosentyx®
Novartis Pharma GmbH
Musculoskeletal system diseases
Axial spondyloarthritis
19,500
100%
additional benefit not proven
01.08.2020
21.01.2021
Ixekizumab (3)
Taltz®
Lilly Deutschland GmbH
Musculoskeletal system diseases
Axial spondyloarthritis
36,300
100%
additional benefit not proven
15.03.2020
03.09.2020
Romosozumab (1)
Evenity®
UCB Pharma GmbH
Musculoskeletal system diseases
Osteoporosis (postmenopausal)
475,000
100%
Indication of
minor additional benefit
01.02.2020
16.07.2020
Upadacitinib (1)
Rinvoq®
AbbVie Deutschland GmbH
Musculoskeletal system diseases
Rheumatoid arthritis (RA)
88,709–188,210
34%
Hint for
considerable additional benefit
15.11.2019
14.05.2020
Belimumab (2)
Benlysta®
GlaxoSmithKline GmbH & Co. KG
Musculoskeletal system diseases
Systemic lupus erythematosus
30–550
100%
Hint for
non-quantifiable additional benefit
01.05.2018
01.11.2018
Tofacitinib (2)
Xeljanz®
Pfizer Pharma GmbH
Musculoskeletal system diseases
Rheumatoid arthritis (RA)
0
29,490–63,815
100%
additional benefit not proven
repealed
15.08.2017
15.02.2018
Sarilumab (1)
Kevzara®
Sanofi-Aventis Deutschland GmbH
Musculoskeletal system diseases
Rheumatoid arthritis (RA)
87,300–184,470
34%
Hint for
considerable additional benefit
01.05.2017
19.10.2017
Tofacitinib (1)
Xeljanz®
Pfizer Pharma GmbH
Musculoskeletal system diseases
Rheumatoid arthritis (RA)
0
87,300–184,470
100%
additional benefit not proven
repealed
01.04.2017
21.09.2017
Baricitinib (1)
Olumiant®
Lilly Deutschland GmbH
Musculoskeletal system diseases
Rheumatoid arthritis (RA)
87,300–184,470
100%
additional benefit not proven
01.06.2016
01.12.2016
Ataluren (2)
Translarna®
PTC Therapeutics International Limited
Musculoskeletal system diseases
Duchenne muscular dystrophy (DMD), ≥ 5 years
0
30–40
100%
minor additional benefit
Orphan
repealed
15.12.2015
02.06.2016
Secukinumab (2)
Cosentyx®
Novartis Pharma GmbH
Musculoskeletal system diseases
Psoriatic arthritis (PA), Radiographic axial spondyloarthritis (AS)Psoriatic arthritis (PA), Bekhterev's disease
40,400–141,600
100%
additional benefit not proven
01.12.2014
21.05.2015
Ataluren (1)
Translarna®
PTC Therapeutics International Limited
Musculoskeletal system diseases
Duchenne muscular dystrophy (DMD), ≥ 5 years
0
82–110
100%
minor additional benefit
Orphan
repealed
27.07.2011
02.08.2012
Belimumab (1)
Benlysta®
GlaxoSmithKline GmbH & Co. KG
Musculoskeletal system diseases
Systemic lupus erythematosus
7,000
100%
Indication of
considerable additional benefit
01.05.2011
19.04.2012
Collagenase aus Clostridium histolyticum (1)
Xiapex®
Pfizer Pharma GmbH
Musculoskeletal system diseases
Dupuytren's contracture
35,000
100%
additional benefit not proven