Cardiovascular diseases

This G-BA category includes all medicinal products for the prevention of stroke, heart attack, heart failure or venous thromboembolism such as pulmonary embolism or deep vein thrombosis, as well as antihypertensives.

To date, the G-BA has assessed XX different medicinal products in XX procedures, which in turn were divided into xx subpopulations. When these subpopulations are weighted according to their share of the total number of patients in the resolution, there is a major additional benefit for xx% and a considerable additional benefit for XX% of the subpopulations. The G-BA has confirmed a minor additional benefit for XX% and a non-quantifiable additional benefit for another XX% in relation to the comparative treatment. The G-BA did recognise no additional benefit for XX% of the subpopulations, corresponding to xx% of the potential total number of all patients using these medicinal products.

All G-BA resolutions concerning cardiovascular diseases

Sotatercept Winrevair® MSD Sharp & Dohme GmbH Cardiovascular diseases Pulmonary arterial hypertension 580–7,850 100% Hint for minor additional benefit Orphan
Enalapril Aqumeldi® Proveca Pharma Limited Cardiovascular diseases Heart failure, < 18 years 0
3,070
100% no additional benefit
Mavacamten Camzyos® Bristol-Myers Squibb GmbH & Co. KGaA Cardiovascular diseases Symptomatic hypertrophic obstructive cardiomyopathy (NYHA Klasse II–III) 18,900–19,500 100% Hint for considerable additional benefit
Riociguat (4) Adempas® MSD Sharp & Dohme GmbH Cardiovascular diseases Pulmonary arterial hypertension, < 18 years of age 5–35 100% no additional benefit
Sacubitril / Valsartan (2) Entresto® Novartis Pharma GmbH Cardiovascular diseases Chronic heart failure with left ventricular dysfunction, ≥ 1 year) 170–860 100% no additional benefit
Dapagliflozin (8) Forxiga® AstraZeneca GmbH Cardiovascular diseases Chronic heart failure with left ventricular ejection fraction LVEF > 40 % 1,270,000–1,400,000 100% Hint for minor additional benefit
Empagliflozin (4) Jardiance® Boehringer Ingelheim Pharma GmbH & Co. KG Cardiovascular diseases Chronic heart failure (CHF) with preserved ejection fraction 1,270,000–1,400,000 100% Hint for minor additional benefit
Vericiguat Verquvo® Bayer Vital GmbH Cardiovascular diseases Chronic heart failure (CHF) 74,600–530,000 100% Hint for minor additional benefit
Empagliflozin (3) Jardiance® Boehringer Ingelheim Pharma GmbH & Co. KG Cardiovascular diseases Chronic heart failure (CHF) 2,061,700–2,273,000 100% Hint for minor additional benefit
Angiotensin-II-Acetat Giapreza® La Jolla Pharmaceutical II B.V. Cardiovascular diseases Hypotension 3,980–37,625 100% no additional benefit
Dapagliflozin (5) Forxiga® AstraZeneca GmbH Cardiovascular diseases Chronic heart failure (CHF) 2,061,700–2,273,000 100% Hint for considerable additional benefit
Riociguat (2, reassessment >€50m) Adempas® MSD Sharp & Dohme GmbH Cardiovascular diseases Chronic thromboembolic pulmonary hypertension 920–5,460 100% no additional benefit Orphan (turnover limit)
Riociguat (3, reassessment >€50m) Adempas® MSD Sharp & Dohme GmbH Cardiovascular diseases Pulmonary arterial hypertension (PAH) 580–7,850 100% no additional benefit Orphan (turnover limit)
Macitentan (2, reassessment >€50m) Opsumit® Actelion Pharmaceuticals Deutschland GmbH Cardiovascular diseases Pulmonary arterial hypertension (PAH) 580–7,850 100% no additional benefit Orphan (turnover limit)
Selexipag Uptravi® Actelion Pharmaceuticals Deutschland GmbH Cardiovascular diseases Pulmonary arterial hypertension (PAH) 580–7,850 100% no additional benefit
Ticagrelor (2) Brilique® AstraZeneca GmbH Cardiovascular diseases Prevention of atherothrombotic events in patients with myocardial infarction and high risk for an atherothrombotic event 105,000 100% Hint for minor additional benefit
Sacubitril / Valsartan Entresto® Novartis Pharma GmbH Cardiovascular diseases Symptomatic chronic heart failure 550,000–1,350,000 68% Hint for considerable additional benefit
Edoxaban Lixiana® Daiichi Sankyo Deutschland GmbH Cardiovascular diseases Prophylaxis of thromboembolic events 1,167,000–1,334,000 81% Indication of minor additional benefit
Apixaban (3) Eliquis® Bristol-Myers Squibb GmbH & Co. KGaA / Pfizer Deutschland GmbH Cardiovascular diseases Treatment and prophylaxis of venous thrombosis and pulmonary embolism 241,000 47% Indication of minor additional benefit
Riociguat Adempas® Bayer Vital GmbH Cardiovascular diseases Pulmonary arterial hypertension (PAH), Chronic thromboembolic pulmonary hypertension (CTPH) 0
1,500–13,310
100% minor additional benefit Orphan
Macitentan Opsumit® Actelion Pharmaceuticals Deutschland GmbH Cardiovascular diseases Pulmonary arterial hypertension (PAH) 0
580–7,850
100% minor additional benefit Orphan
Apixaban (2) Eliquis® Bristol-Myers Squibb GmbH & Co. KGaA / Pfizer Deutschland GmbH Cardiovascular diseases Prophylaxis of strokes and systemic embolisms 926,000–1,093,000 100% Indication of minor additional benefit
Apixaban Eliquis® Bristol-Myers Squibb GmbH & Co. KGaA / Pfizer Deutschland GmbH Cardiovascular diseases Prophylaxis of venous thromboembolism 390,000 58% Indication of minor additional benefit
Aliskiren / Amlodipin Rasilamlo® Novartis Pharma GmbH Cardiovascular diseases Essential hypertension, add-on therapy 156,600–565,900 100% no additional benefit
Azilsartan Medoxomil Edarbi® Takeda Pharma GmbH Cardiovascular diseases Arterial hypertension 0 100% no additional benefit
Ticagrelor Brilique® AstraZeneca GmbH Cardiovascular diseases Prevention of atherothrombotic events in acute coronary syndrome 220,000–269,000 82% Proof of considerable additional benefit